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Sanskrit Name - Kadamb
Botanical Name - Anthocephalus indicus
Family - Rubiaceae
Common Names - Neep, Priyak, Vritpushp, Halipriya, Kadam, Kadamgaach, Raajkadamb
Anthocephalus indicus A. Rich. is a medicinally important plant. It is used to treat the various remedies and diseases. It is mentioned in the literature that he phytoconsituents present in the plant is used for diabetes. The present study aims to examine the antidiabetic potential of aqueous extract of Anthocephalus indicusA. Rich. fruits.
Material and Methods: Sprague Dawley adult male rats weighing 150-180g were used for the study. Alloxan monohydrate was used to induce diabetes. Aqueous extract of Anthocephalus indicus fruit (400 mg/kg body weight) was orally administered to the diabetic rats for 21 days. The serum glucose, total cholesterol, triglycerides, HDL and LDL were studied. The preliminary phytochemical analysis of the aqueous fruit extract was carried out to detect the presence of alkaloid, flavonoid, tannins, glycosides, steroids, phenols coumarins and quinones. The histopathological study of liver and pancreas of rats of all the groups was done by haematoxylin and eosin staining technique.
Results: The serum glucose level, total cholesterol, triglycerides and LDL was significantly decreased while HDL level was significantly increased in the extract treated diabetic rats. The histopathological study results revealed that the liver and pancreatic cells of extract treated diabetic rats altered back to the near cells of the normal rats. Preliminary phytochemical analysis of aqueous fruit extract of the plant revealed the presence of
alkaloids, flavonoids, tannins, glycosides, phenols, coumarins and quinones.
Conclusion: The results suggest that the aqueous extract of Anthocephalus indicus fruits possess antidiabetic activity and can be used as potent natural antidiabetic drug.